Potassium Carbonate → HCID 59558422, compound

HRID 1175170Notes

Reaction equation

HRID 1175170 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([F:8])[CH:7]=1.Br[CH2:11][CH2:12][O:13][CH2:14]CBr.C([O-])([O-])=O.[K+].[K+].C([O-])(O)=O.[Na+]>CN(C=O)C.C(OCC)(=O)C>[Br:1][C:2]1[CH:3]=[C:4]([O:9][CH2:11][CH2:12][O:13][CH3:14])[CH:5]=[C:6]([F:8])[CH:7]=1

Participants

7

Reactant 4

HCID 11430Potassium CarbonateHCID 21521Bis(2-bromoethyl) etherHCID 516892Sodium BicarbonateHCID 219046363-Bromo-5-fluorophenol

Product 1

HCID 59558422HCID 59558422, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

3-Bromo-5-fluoro-phenol (5.0 g, 26.2 mmol), 2-bromoethylether (4.0 g, 28.8 mmol) and K2CO3 (4.4 g, 31.4 mmol) are mixed in 50 ml DMF and stirred at 50 C overnight. Addition of aqueous NaHCO3 solution and extraction into ethyl acetate yields the title compound.

Sources & evidence

ORD record
ord-28c635fa97fb405ca8c2bc8875851d50
Source dataset
uspto-grants-2010_11
Patent number
US07838674B2

Reaction notes

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