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HRID1176733

反应详情

EQUATION

反应方程式

HRID 1176733 的结构方程式

REACTANTS

反应物

4
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：CC(C)(C)OC(=O)Nc1ccccc1N
HCID676311

Tert-butyl (2-aminophenyl)carbamate

C11H16N2O2

结构：Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)O)c2)cc1
HCID66646287

未命名化合物

2 次

PRODUCTS

生成物

1
结构：Cc1ccc(S(=O)(=O)n2ccc(/C=C/C(=O)Nc3ccccc3NC(=O)OC(C)(C)C)c2)cc1
HCID86613977

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

Starting materials: (E)-3-[1-(toluene-4-sulfonyl)-1H-pyrrol-3yl]-acrylic acid (compound A1) (0.400 g), HOBtH2O (0.285 g), triethylamine (652 μl), DMF (25 ml), EDC?HCl (0.698 g), N—BOC-1,2-phenylenediamine (0.286 g). Reaction conditions: room temperature, 1 hour; room temperature, 2 hours.

WORKUP

后处理

  1. customReaction conditions
  2. customroom temperature, 1 hour
  3. customroom temperature, 2 hours