Hydroxylamine → HCID 10109597, compound

HRID 1180548Notes

Reaction equation

HRID 1180548 reaction equation
[CH3:1][N:2]([S:10]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]=[C:22]=[CH:23][CH3:24])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[C@H:3]([C:7](O)=[O:8])[CH:4]([CH3:6])[CH3:5].[OH:25][N:26]1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC.CN1CCOCC1.NO>CN(C)C=O>[OH:25][NH:26][C:7](=[O:8])[CH:3]([N:2]([CH3:1])[S:10]([C:13]1[CH:18]=[CH:17][C:16]([O:19][CH2:20][CH:21]=[C:22]=[CH:23][CH3:24])=[CH:15][CH:14]=1)(=[O:12])=[O:11])[CH:4]([CH3:6])[CH3:5]

Participants

7

Reactant 5

HCID 787HydroxylamineHCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 86588658HCID 86588658, compound

Product 1

HCID 10109597HCID 10109597, compoundYield 63%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The procedure of Example 13 was followed using the product from Example 21 (185 mg, 0.52 mmol), 1-hydroxybenzotriazol (84 mg, 0.62 mmol), 1-[3-(dimethylamino)-propyl]-3-ethylcarbodimide hydrochloride (140 mg, 0.73 mmol), N-methylmorpholine (0.86 mmol, 0.78 mmol), and hydroxylamine (0.159 ml, 2.6 mmol) in dimethylformamide (5 ml) to give 120 mg (63%) of the product.

Sources & evidence

ORD record
ord-d84c5e85ab6f48da9ba2967d6b1f6b9e
Source dataset
uspto-grants-2007_10
Patent number
US07282496B2

Reaction notes

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