反应详情

To a solution of 10 g of (S)-Pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester in 953 ml of DMF, 9.2 g of HOBT, 11.5 g of EDC, 3.4 g of cyclopropylamine and 13.8 g of DIPEA was added and the reaction mixture was stirred for 16 h at RT. Then, the reaction mixture was diluted with saturated aqueous sodium hydrogen carbonate solution and extracted with ethyl acetate. The organic phase was washed with saturated aqueous sodium hydrogen carbonate solution and water and dried over MgSO4. The solvents were removed under reduced pressure and the crude product was pure enough for the next reaction step.

1. extractionextracted with ethyl acetate
2. washThe organic phase was washed with saturated aqueous sodium hydrogen carbonate solution and water
3. dry with materialdried over MgSO4
4. customThe solvents were removed under reduced pressure
5. customthe crude product was pure enough for the next reaction step