Hydrochloric Acid → 2-[1-m-Tolyl-meth-(e)-ylidene]-succinic acid diethyl ester
Reaction equation
[CH3:1][CH2:2][O-:3].[Na+].[CH3:5][C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[CH:9]=O.C(O[C:17](=O)[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])C.Cl.[CH2:26]([OH:28])C>>[CH2:2]([O:3][C:26](=[O:28])/[C:17](=[CH:9]/[C:8]1[CH:7]=[C:6]([CH3:5])[CH:13]=[CH:12][CH:11]=1)/[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH3:1]Participants
6
Procedure
To a solution of 22.6 g sodium ethylate in 440 ml of ethanol, 20 g of 3-Methyl-benzaldehyde and 31 g of Malonic acid diethyl ester dissolved in 100 ml ethanol was added drop-wise over 1.5 h at 50° C. Then, the reaction mixture was heated to reflux for 12 h. After cooling to RT half of the solvent was evaporated under reduced pressure and diluted with 200 ml of water. The remaining reaction mixture was acidified to pH 1 by addition of concentrated hydrochloric acid and then extracted with ethyl acetate. The organic phase was dried over MgSO4 and the solvents were removed under reduced pressure. The crude product was pure enough for the next reaction step.
Workup
- additionwas added drop-wise over 1.5 h at 50° C
- temperatureThen, the reaction mixture was heated
- temperatureto reflux for 12 h
- customwas evaporated under reduced pressure
- additiondiluted with 200 ml of water
- customThe remaining reaction mixture
- extractionextracted with ethyl acetate
- dry with materialThe organic phase was dried over MgSO4
- customthe solvents were removed under reduced pressure
- customThe crude product was pure enough for the next reaction step
Sources & evidence
- ORD record
- ord-856b0933d5a644fb8a7417c8e1615e3f
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08669266B2
Reaction notes
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