Ethyl chloroformate → ethyl 4-iodo-2-methyl-1H-imidazole-1-carboxylate
Reaction equation
[I:1][C:2]1[N:3]=[C:4]([CH3:7])[NH:5][CH:6]=1.CCN(C(C)C)C(C)C.Cl[C:18]([O:20][CH2:21][CH3:22])=[O:19]>C1COCC1.CN(C1C=CN=CC=1)C>[I:1][C:2]1[N:3]=[C:4]([CH3:7])[N:5]([C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:6]=1Participants
Conditions
- Temperature
- 0 °C
Procedure
In general, modifications were made from the procedure given in J. Org. Chem., 1999, 64, 23, 8608-8615. A solution of commercially available 4-iodo-2-methyl-1H-imidazole (520 mg, 2.5 mmol) in THF (8.3 mL), containing DIEA (1.07 mL, 6.25 mmol) and DMAP (150 mg, 1.30 mmol), was cooled in a ice bath at 0° C. A solution of ethyl chloroformate (678 mg, 6.25 mmol) in THF (2.5 mL) was slowly added over a period of 20 min to the reaction mixture. The reaction mixture was heated at 50° C. for 48h and the solvent was removed under reduced pressure. The residue was dissolved in DCM and the organic layer was washed with brine, water, dried over MgSO4, filtered and evaporated. Purification by flash chromatography (prepacked 10 g silicagel column, DCM/MeOH:97/3 as eluent) to afford 660 mg of ethyl 4-iodo-2-methyl-1H-imidazole-1-carboxylate (Yield: 94%) as a colorless oil.
Workup
- customthe solvent was removed under reduced pressure
- dissolutionThe residue was dissolved in DCM
- washthe organic layer was washed with brine, water
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customPurification by flash chromatography (prepacked 10 g silicagel column, DCM/MeOH:97/3 as eluent)
Sources & evidence
- ORD record
- ord-58a742dd3c4145d6b586c2ed5af869c6
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08674106B2
Reaction notes
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