Hydrochloric Acid → HCID 86666480, compound

HRID 1189677Notes

Reaction equation

HRID 1189677 reaction equation
[CH3:1][NH2:2].[Cl:3][C:4]1[C:12]([CH3:13])=[C:11](F)[C:10]([N+:15]([O-:17])=[O:16])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].Cl>C1COCC1>[Cl:3][C:4]1[C:12]([CH3:13])=[C:11]([NH:2][CH3:1])[C:10]([N+:15]([O-:17])=[O:16])=[CH:9][C:5]=1[C:6]([OH:8])=[O:7]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 105138312-Chloro-4-fluoro-3-methyl-5-nitrobenzoic acid

Product 1

HCID 86666480HCID 86666480, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A mixture of methylamine (2M THF solution, 8.56 mL, 17 mmol), 2-chloro-3-methyl-4-fluoro-5-nitro-benzoic acid (1.00 g, 4.2 mmol) and 20 mL THF is stirred over the weekend at rt. Then the mixture is acidified with 4M aq HCl and concentrated and the residue is washed with water and dried.

Workup

  1. concentrationconcentrated
  2. washthe residue is washed with water
  3. customdried

Sources & evidence

ORD record
ord-46e8bf2cb2f348248942264f95efac78
Source dataset
uspto-grants-2014_03
Patent number
US08674113B2

Reaction notes

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