反应详情

Add pyrrolidine (0.89 mL, 10.74 mmol) to a stirred solution of 4-bromomethyl-benzonitrile (1 g, 5.1 mmol) and triethylamine (1.5 mL, 10.74 mmol) in anhydrous THF (26 mL). Stir reaction overnight at room temperature. Partition the reaction mixture between EtOAc and water. Extract the aqueous phase twice with EtOAc. Dry the combined organic extracts over MgSO4, filter, and concentrate in vacuo to obtain the desired intermediate (918 mg, 97%) suitable for use without further purification. MS (APCI+) m/z: 187 (M+H)+.

1. customreaction overnight at room temperature
2. customPartition the reaction mixture between EtOAc and water
3. extractionExtract the aqueous phase twice with EtOAc
4. dry with materialDry the combined organic extracts over MgSO4
5. filtrationfilter
6. concentrationconcentrate in vacuo