Sodium Iodide → HCID 68908687, compound

HRID 1191475Notes

Reaction equation

[CH2:1]([CH:5]1[CH2:11][CH:10]2[NH:12][CH:7]([CH2:8][CH2:9]2)[CH2:6]1)[CH2:2][CH2:3][CH3:4].[Na+].[I-].C([O-])([O-])=O.[K+].[K+].[CH3:21][N:22]([CH:24]=[O:25])[CH3:23]>>[CH2:1]([CH:5]1[CH2:6][CH:7]2[N:12]([CH2:9][C@@H:10]([CH3:11])[CH2:21][N:22]3[C:23]4[C:6](=[CH:5][CH:1]=[CH:2][CH:3]=4)[CH2:7][CH2:8][C:24]3=[O:25])[C@@H:10]([CH2:9][CH2:8]2)[CH2:11]1)[CH2:2][CH2:3][CH3:4]

Participants

Reactant 4

HCID 5238Sodium Iodide

HCID 6228Dimethylformamide

HCID 11430Potassium Carbonate

HCID 689079663-Butyl-8-azabicyclo[3,2,1]octane

Product 1

HCID 68908687HCID 68908687, compound

Procedure

Crude (R,S)-1-(3-chloro-2-methylpropyl)-3,4-dihydro-1H-quinolin-2-one (107LH63) (0.094 g), 3-butyl-8-azabicyclo[3.2.1]octane (0.025 g, 0.15 mmol), NaI (0.100 g, 0.67 mmol), and K2CO3 (0.075 g, 0.54 mmol) in DMF (1 mL) were reacted and purified according to GP20 to give the title compound (107LH74-c4) (0.025 g). HPLC-MS (ammonium acetate) [M+H]+=369.33.

Workup

custompurified

Sources & evidence

ORD record: ord-0adcdd49d19643bebc6ba7134a109da7
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08680115B2

Reaction notes

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