反应详情

温度

90 °C

A mixture of 3-methyl-2-nitrophenol (50 g, 0.326 mol), K2CO3 (45 g, 0.326 mol) and benzylbromide (61.4 g, 42.6 mL, 0.359 mol) in dry DMF (200 mL) was stirred at 90° C. for 3 hours under nitrogen. Most of the DMF was removed at reduced pressure and the residue was partitioned between water (300 mL) and ether (300 mL). The organic layer was washed with brine and dried (Na2SO4). Removal of the solvent provided (70 g, 88%) of 3-benzyloxy-2-nitrotoluene as an orange oil.

1. customMost of the DMF was removed at reduced pressure
2. customthe residue was partitioned between water (300 mL) and ether (300 mL)
3. washThe organic layer was washed with brine
4. dry with materialdried (Na2SO4)
5. customRemoval of the solvent