Hydrochloric Acid → HCID 53945931, compound

HRID 1195836Notes

Reaction equation

HRID 1195836 reaction equation
[C:1]1([C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH3:16])([OH:9])[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].[CH3:19]I.Cl>O1CCCC1>[CH3:19][O:9][C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)([C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[CH3:16])[CH3:8]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 12252137HCID 12252137, compound

Product 1

HCID 53945931HCID 53945931, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 g of 1-Phenyl-1-tolylethanol are stirred overnight with 0.56 g of 80% NaH in 50 ml of tetrahydrofuran, 3.7 g of methyliodide added and stirring continued for 6 hours. The mixture is worked up with aq. HCl, extracted with dichloromethane and the oily product purified over a silica gel column with cyclohexane as eluant.

Workup

  1. additionadded
  2. extractionextracted with dichloromethane
  3. customthe oily product purified over a silica gel column with cyclohexane as eluant

Sources & evidence

ORD record
ord-867d1899a54249deb48caf5a0fbfbc53
Source dataset
uspto-grants-1992_05
Patent number
US05112851

Reaction notes

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