反应详情

Ethyl acetoacetate (11.8g, 0.092 moles), paraoctylbenzaldehyde (10.0 g, 0.046 moles) and piperidine (1.5ml) were stirred for 48 hrs. at room temperature. Ethyl acetate (50ml) was added and the solution was added to water (100ml). The layers were separated and the organic layer dried over anhydrous sodium sulfate, filtered and concentrated to an oily solid. The title products were separated and purified by silica gel chromatography. The structure assignments were supported by NMR, infrared spectra and elemental analysis (330.5)

1. customat room temperature
2. customThe layers were separated
3. dry with materialthe organic layer dried over anhydrous sodium sulfate
4. filtrationfiltered
5. concentrationconcentrated to an oily solid
6. customThe title products were separated
7. custompurified by silica gel chromatography