Hydrochloric Acid → 3-tert-butylsulfanyl-N-[2-(1,3-dioxoisoindol-2-yl)ethyl]-4-[(4-phenoxyphenyl)sulfonylamino]pyrrolidine-1-carboxamide

HRID 1206494Notes

Reaction equation

HRID 1206494 reaction equation
[C:2]([O:4][C:3]([CH3:5])([CH3:6])[CH3:7])(=[O:8])[N:9]1[CH2:10][CH:11]([NH:19][S:20](=[O:21])(=[O:22])[c:23]2[cH:24][cH:25][c:26]([O:29][c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[cH:27][cH:28]2)[CH:12]([S:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:13]1.[C:58]1(=[O:71])[c:59]2[c:60]([cH:67][cH:68][cH:69][cH:70]2)[C:61](=[O:66])[N:62]1[CH2:63][CH2:64][NH2:65].[CH3:72][CH2:73][O:74][C:75](=[O:76])[CH3:77].[CH:36]([N:37]([CH:38]([CH3:39])[CH3:40])[CH2:41][CH3:42])([CH3:43])[CH3:44].[Cl:45][C:46]([Cl:47])([O:48][C:49](=[O:50])[O:51][C:52]([Cl:53])([Cl:54])[Cl:55])[Cl:56].[Cl:78][CH2:79][Cl:80].[ClH:1].[ClH:57]>>[C:2](=[O:4])([N:9]1[CH2:10][CH:11]([NH:19][S:20](=[O:21])(=[O:22])[c:23]2[cH:24][cH:25][c:26]([O:29][c:30]3[cH:31][cH:32][cH:33][cH:34][cH:35]3)[cH:27][cH:28]2)[CH:12]([S:14][C:15]([CH3:16])([CH3:17])[CH3:18])[CH2:13]1)[NH:65][CH2:64][CH2:63][N:62]1[C:58](=[O:71])[c:59]2[c:60]([cH:67][cH:68][cH:69][cH:70]2)[C:61]1=[O:66]

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 6344DichloromethaneHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 94429TriphosgeneHCID 12753432-(2-Aminoethyl)-1H-isoindole-1,3(2H)-dioneHCID 67232768Tert-butyl 3-tert-butylsulfanyl-4-[(4-phenoxyphenyl)sulfonylamino]pyrrolidine-1-carboxylate

Product 1

HCID 672333863-tert-butylsulfanyl-N-[2-(1,3-dioxoisoindol-2-yl)ethyl]-4-[(4-phenoxyphenyl)sulfonylamino]pyrrolidine-1-carboxamide

Sources & evidence

ORD record
ord-2b902f65162a4f719546b0b5423b3f6b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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