Hydrochloric Acid → Benzyl 3-amino-2,6-difluorobenzoate

HRID 121675Notes

Reaction equation

HRID 121675 reaction equation
[CH2:10]([Li:11])[CH2:12][CH2:13][CH3:14].[Cl:15][Si:16]([CH3:17])([CH3:18])[CH2:19][CH2:20][Si:21]([Cl:22])([CH3:23])[CH3:24].[Cl:25][C:26](=[O:27])[O:28][CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1.[ClH:36].[F:1][c:2]1[c:3]([NH2:9])[cH:4][cH:5][c:6]([F:8])[cH:7]1.[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[F:1][c:2]1[c:3]([NH2:9])[cH:4][cH:5][c:6]([F:8])[c:7]1[C:26](=[O:27])[O:28][CH2:29][c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 97092,4-DifluoroanilineHCID 10387Benzyl chloroformateHCID 835521,2-Bis(chlorodimethylsilyl)ethaneHCID 178418339Butyllithium

Product 1

HCID 53396458Benzyl 3-amino-2,6-difluorobenzoate

Sources & evidence

ORD record
ord-c31619a0054043d1a306727b3b2af0a6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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