1,2-Dichloroethane → N-[4-(3-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]-2-(3-pyridyl)acetamide

HRID 1217352Notes

Reaction equation

HRID 1217352 reaction equation
[CH2:31]([Cl:32])[CH2:33][Cl:34].[CH3:47][CH2:48][N:49]([CH2:50][CH3:51])[CH2:52][CH3:53].[ClH:20].[ClH:35].[Na+:54].[O:1]1[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[c:9]2[c:10](-[c:15]3[cH:16][o:17][cH:18][cH:19]3)[n:11][c:12]([NH2:14])[s:13]2)[CH2:5][CH2:6]1.[O:59]=[CH:60][N:61]([CH3:62])[CH3:63].[OH2:36].[OH:37][n:38]1[c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]2[n:45][n:46]1.[OH:55][C:56](=[O:57])[O-:58].[n:21]1[cH:22][c:23]([CH2:27][C:28](=[O:29])[OH:30])[cH:24][cH:25][cH:26]1>>[O:1]1[CH2:2][CH2:3][CH:4]([C:7](=[O:8])[c:9]2[c:10](-[c:15]3[cH:16][o:17][cH:18][cH:19]3)[n:11][c:12]([NH:14][C:28]([CH2:27][c:23]3[cH:22][n:21][cH:26][cH:25][cH:24]3)=[O:29])[s:13]2)[CH2:5][CH2:6]1

Participants

11

Reactant 10

HCID 111,2-DichloroethaneHCID 1083-Pyridineacetic acidHCID 313Hydrochloric Acid2×HCID 769Bicarbonate IonHCID 923Sodium ionHCID 962WaterHCID 6228DimethylformamideHCID 8471TriethylamineHCID 757711-HydroxybenzotriazoleHCID 866124732-Amino-4-(3-furyl)thiazol-5-yl tetrahydropyran-4-yl ketone

Product 1

HCID 23144488N-[4-(3-Furyl)-5-(tetrahydropyran-4-ylcarbonyl)thiazol-2-yl]-2-(3-pyridyl)acetamide

Sources & evidence

ORD record
ord-4c4fb519c097498a90e612b0e652226d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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