Ammonium → 2-Chloro-4-phenylpyrimidine

HRID 1221748Notes

Reaction equation

HRID 1221748 reaction equation
[Br-:9].[CH2:19]1[O:20][CH2:21][CH2:22][CH2:23]1.[Cl-:17].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([Cl:8])[n:7]1.[NH4+:18].[Pd:24].[c:10]1([Zn+:16])[cH:11][cH:12][cH:13][cH:14][cH:15]1.[c:25]1([P:26]([c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[cH:39][cH:40][cH:41][cH:42][cH:43]1.[c:44]1([P:45]([c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[c:52]2[cH:53][cH:54][cH:55][cH:56][cH:57]2)[cH:58][cH:59][cH:60][cH:61][cH:62]1.[c:63]1([P:64]([c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[c:71]2[cH:72][cH:73][cH:74][cH:75][cH:76]2)[cH:77][cH:78][cH:79][cH:80][cH:81]1.[c:82]1([P:83]([c:84]2[cH:85][cH:86][cH:87][cH:88][cH:89]2)[c:90]2[cH:91][cH:92][cH:93][cH:94][cH:95]2)[cH:96][cH:97][cH:98][cH:99][cH:100]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[n:7]1

Participants

9

Reactant 8

HCID 223AmmoniumHCID 259Bromide ionHCID 312ChlorideHCID 8028TetrahydrofuranHCID 11776Triphenylphosphine4×HCID 23938PalladiumHCID 775312,4-DichloropyrimidineHCID 178528053HCID 178528053, compound

Product 1

HCID 6053562-Chloro-4-phenylpyrimidine

Sources & evidence

ORD record
ord-9213777896bb430fbd20e1b4921a61e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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