Tetrahydrofuran → Di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate

HRID 1224280Notes

Reaction equation

HRID 1224280 reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH:24]([C:36](=[O:37])[OH:38])[CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cl:8][C:9]([O:10][CH2:11][CH:12]([CH3:13])[CH3:14])=[O:15].[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1>>[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH:24]([CH2:36][OH:37])[CH2:25][N:26]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:27][CH2:28]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 62365Isobutyl chloroformateHCID 112559791,4-Di-Boc-piperazine-2-carboxylic acid

Product 1

HCID 22711445Di-tert-butyl 2-(hydroxymethyl)piperazine-1,4-dicarboxylate

Sources & evidence

ORD record
ord-47b91612ed5940bfbbdabccdcee2b93e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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