Dimethylformamide → Trifluoroacetic acid

HRID 1230313Notes

Reaction equation

HRID 1230313 reaction equation
[CH3:48][C:49]([CH3:50])([CH3:51])[NH2:52].[CH:39]([N:40]([CH2:41][CH3:42])[CH:43]([CH3:44])[CH3:45])([CH3:46])[CH3:47].[Cl:8][c:9]1[cH:10][c:11]([C:12](=[O:13])[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20](=[O:21])[OH:22])[CH:23]([CH3:24])[CH3:25])[cH:26][c:27]([O:29][CH2:30][CH2:31][NH:32][c:33]2[cH:34][cH:35][n:36][cH:37][cH:38]2)[cH:28]1.[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7].[O:53]=[CH:54][N:55]([CH3:56])[CH3:57]>>[Cl:8][c:9]1[cH:10][c:11]([C:12](=[O:13])[N:14]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][C:20](=[O:21])[NH:52][C:49]([CH3:48])([CH3:50])[CH3:51])[CH:23]([CH3:24])[CH3:25])[cH:26][c:27]([O:29][CH2:30][CH2:31][NH:32][c:33]2[cH:34][cH:35][n:36][cH:37][cH:38]2)[cH:28]1.[F:1][C:2]([C:3](=[O:4])[OH:5])([F:6])[F:7]

Participants

7

Reactant 5

HCID 6228DimethylformamideHCID 6385Tert-ButylamineHCID 6422Trifluoroacetic acidHCID 81531DiisopropylethylamineHCID 18349003HCID 18349003, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 18348960HCID 18348960, compound

Sources & evidence

ORD record
ord-ffea3ac7018d4a8eb47581e11373757f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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