Tetrahydrofuran → 4-[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

HRID 1231698Notes

Reaction equation

HRID 1231698 reaction equation
[C:28](#[CH:29])[c:30]1[n:31][c:32]([CH3:42])[n:33](-[c:35]2[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]2)[cH:34]1.[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[CH2:48]1[CH2:49][CH2:50][NH:51][CH2:52][CH2:53]1.[Cu:54][I:55].[I:1][c:2]1[cH:3][c:4]([CH3:8])[n:5][cH:6][cH:7]1.[c:9]1([P:10]([c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)[cH:23][cH:24][cH:25][cH:26][cH:27]1>>[c:2]1([C:29]#[C:28][c:30]2[n:31][c:32]([CH3:42])[n:33](-[c:35]3[cH:36][cH:37][c:38]([F:41])[cH:39][cH:40]3)[cH:34]2)[cH:3][c:4]([CH3:8])[n:5][cH:6][cH:7]1

Participants

7

Reactant 6

HCID 8028TetrahydrofuranHCID 8082PiperidineHCID 11776TriphenylphosphineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 116655954-Ethynyl-1-(4-fluorophenyl)-2-methyl-1H-imidazoleHCID 126913224-Iodo-2-methylpyridine

Product 1

HCID 100856604-[1-(4-Fluoro-phenyl)-2-methyl-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

Sources & evidence

ORD record
ord-24680688feb84887b5c9a6dbc78aa932
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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