Acetone → 3-(4-{[2-(4-Chloro-phenyl)-4-(2-hydroxy-ethyl)-thiazole-5-carbonyl]-amino}-2-methoxy-phenoxy)-azetidine-1-carboxylic acid tert-butyl ester
Reaction equation
[BH4-:1].[C:3]([CH3:4])([CH3:5])([CH3:6])[O:7][C:8](=[O:9])[N:10]1[CH2:11][CH:12]([O:14][c:15]2[c:16]([O:41][CH3:42])[cH:17][c:18]([NH:21][C:22](=[O:23])[c:24]3[c:25]([CH2:36][C:37](=[O:38])[O:39][CH3:40])[n:26][c:27](-[c:29]4[cH:30][cH:31][c:32]([Cl:35])[cH:33][cH:34]4)[s:28]3)[cH:19][cH:20]2)[CH2:13]1.[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[CH3:43][C:44](=[O:45])[CH3:46].[CH3:47][CH2:48][O:49][C:50](=[O:51])[CH3:52].[Li+:2].[OH2:58]>>[C:3]([CH3:4])([CH3:5])([CH3:6])[O:7][C:8](=[O:9])[N:10]1[CH2:11][CH:12]([O:14][c:15]2[c:16]([O:41][CH3:42])[cH:17][c:18]([NH:21][C:22](=[O:23])[c:24]3[c:25]([CH2:36][CH2:37][OH:38])[n:26][c:27](-[c:29]4[cH:30][cH:31][c:32]([Cl:35])[cH:33][cH:34]4)[s:28]3)[cH:19][cH:20]2)[CH2:13]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-e67079cfdbe64a489cd2d5106ca73f26
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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