Water → Ethyl 1-benzyl-4-fluoropiperidine-4-carboxylate

HRID 1237174Notes

Reaction equation

HRID 1237174 reaction equation
[CH2:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[N:22]1[CH2:23][CH2:24][CH:25]([C:28](=[O:29])[O:30][CH2:31][CH3:32])[CH2:26][CH2:27]1.[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[CH3:10][CH2:11][CH2:12][CH2:13][Li:14].[CH3:58][CH2:59][O:60][C:61]([CH3:62])=[O:63].[CH:1]([N:2]([CH2:3][CH3:4])[CH:5]([CH3:6])[CH3:7])([CH3:8])[CH3:9].[F:33][N:34]([S:35]([c:36]1[cH:37][cH:38][cH:39][cH:40][cH:41]1)(=[O:42])=[O:43])[S:44]([c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1)(=[O:51])=[O:52].[OH2:64]>>[CH2:15]([c:16]1[cH:17][cH:18][cH:19][cH:20][cH:21]1)[N:22]1[CH2:23][CH2:24][C:25]([C:28](=[O:29])[O:30][CH2:31][CH3:32])([F:33])[CH2:26][CH2:27]1

Participants

8

Reactant 7

HCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 81531DiisopropylethylamineHCID 90423Ethyl 1-benzylpiperidine-4-carboxylateHCID 588007N-FluorobenzenesulfonimideHCID 178418339Butyllithium

Product 1

HCID 66980618Ethyl 1-benzyl-4-fluoropiperidine-4-carboxylate

Sources & evidence

ORD record
ord-87dff789b60c402091b567181393a6d8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Reaction notes

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