Cesium carbonate → 1-(but-3-en-1-yl)pyrrolidine
Reaction equation
Br[CH2:2][CH2:3][CH:4]=[CH2:5].[NH:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1.C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C>[CH2:2]([N:6]1[CH2:10][CH2:9][CH2:8][CH2:7]1)[CH2:3][CH:4]=[CH2:5]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 120 °C
Procedure
4-Bromo-but-1-ene (81 mg, 0.6 mmol) was added dropwise to a stirred suspension of pyrrolidine (50 μL, 0.6 mmol) and Cs2CO3 (196 mg, 0.6 mmol) in 1 mL DMF. The mixture was heated to 120° C. using microwave for 20 min, then filtered and used for the next step directly without purification.
Workup
- customfor 20 min
- filtrationfiltered
- customused for the next step directly without purification
Sources & evidence
- ORD record
- ord-652fca441a4a47c7b72b35d2c4ab736f
- Source dataset
- uspto-grants-2006_10
- Patent number
- US07119205B2
Reaction notes
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