Potassium Carbonate → HCID 18327278, compound

HRID 1250149Notes

Reaction equation

HRID 1250149 reaction equation
[Cl:1][C:2]1[C:3]([CH2:12][C:13]2[CH:18]=[CH:17][C:16]([OH:19])=[C:15]([Cl:20])[C:14]=2[Cl:21])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:29][C:30]([O:32][CH3:33])=[O:31]>CN(C)C=O>[Cl:20][C:15]1[C:14]([Cl:21])=[C:13]([CH2:12][C:3]2[C:2]([Cl:1])=[CH:7][C:6]([C:8]([F:10])([F:9])[F:11])=[CH:5][N:4]=2)[CH:18]=[CH:17][C:16]=1[O:19][CH2:29][C:30]([O:32][CH3:33])=[O:31]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 18327274HCID 18327274, compound

Product 1

HCID 18327278HCID 18327278, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

At 23° C., 2.0 g of 3-chloro-2-(2,3-dichloro-4-hydroxybenzyl)-5-trifluoromethylpyridine, 1.5 g of anhydrous potassium carbonate and 1.0 g of methyl bromoacetate were stirred in 60 ml of anhydrous dimethylformamide for 16 hours. The reaction mixture was then poured into 400 ml of ice-water. The resulting solid product was separated off, washed with water and purified by stirring in n-hexane. Yield: 2.4 g (100%; white crystals); mp.: 110-111° C.

Workup

  1. customThe resulting solid product was separated off
  2. washwashed with water
  3. custompurified

Sources & evidence

ORD record
ord-51b43eaa8f404d9ea376ca72e477273e
Source dataset
uspto-grants-2002_01
Patent number
US06337305B1

Reaction notes

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