Potassium Carbonate → 4-Chloro-5-(4-methyl-piperazin-1-yl)-2-nitro-N-methyl-aniline

HRID 1258671Notes

Reaction equation

HRID 1258671 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Cl:8][C:9]1[C:16](Cl)=[CH:15][C:12]([NH:13][CH3:14])=[C:11]([N+:18]([O-:20])=[O:19])[CH:10]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:8][C:9]1[C:16]([N:5]2[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]2)=[CH:15][C:12]([NH:13][CH3:14])=[C:11]([N+:18]([O-:20])=[O:19])[CH:10]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 531671-MethylpiperazineHCID 2893174,5-Dichloro-n-methyl-2-nitroaniline

Product 1

HCID 441206494-Chloro-5-(4-methyl-piperazin-1-yl)-2-nitro-N-methyl-aniline

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The sub-title compound was prepared from N-methylpiperazine (200 mg, 2.0 mmol), 4,5-dichloro-N-methyl-2-nitroaniline (442 mg, 2.0 mmol) and potassium carbonate (304 mg, 2.2 mmol) in DMF (10 mL) in accordance to example 9 step (d).

Sources & evidence

ORD record
ord-492806d2163048e0a65034046d569426
Source dataset
uspto-grants-2013_06
Patent number
US08466186B2

Reaction notes

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