反应详情

A suspension of 1 g of 2-amino-7-chloro-N-methyl-4-oxo-1-(pyridin-2-ylmethyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide (2.91 mmol) in a mixture of 20 ml of dimethylformamide and 5.7 ml of triethylamine is placed in an 80 ml microwave tube. This suspension is sparged with argon and then 0.498 g of (±)-1-methoxy-2-methyl-3-butyn-2-ol (4.36 mmol), 0.055 g of CuI (0.29 mmol) and 0.102 g of bis(triphenylphosphine)palladium(II)dichloride (0.15 mmol) are successively added.

1. customis placed in an 80 ml microwave tube
2. customThis suspension is sparged with argon