Hydrochloric Acid → HCID 18456052, compound

HRID 1272340Notes

Reaction equation

HRID 1272340 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:6]([N:13]1[CH2:18][CH2:17][N:16]([C:19]2[C:20]([CH3:33])=[C:21]([CH3:32])[C:22]3[O:26][C:25]([CH3:28])([CH3:27])[CH:24](O)[C:23]=3[C:30]=2[CH3:31])[CH2:15][CH2:14]1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1.[ClH:34]>C(OCC)(=O)C>[ClH:34].[ClH:34].[CH2:6]([N:13]1[CH2:18][CH2:17][N:16]([C:19]2[C:20]([CH3:33])=[C:21]([CH3:32])[C:22]3[O:26][C:25]([CH3:27])([CH3:28])[CH:24]([N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)[C:23]=3[C:30]=2[CH3:31])[CH2:15][CH2:14]1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 31268PyrrolidineHCID 67422225HCID 67422225, compound

Product 1

HCID 18456052HCID 18456052, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

Using pyrrolidine and 5-(4-benzyl piperazin-1-yl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-3-ol obtained in Reference Example 42, the free base was obtained in the same manner as in Example 57. The free base was treated with a 4 N hydrochloric acid in ethyl acetate solution (10 ml) to obtain the title compound. Yield 93%. mp. 224–227° C. (decomposition) (ethyl acetate-ethanol).

Workup

  1. customobtained in Reference Example 42
  2. customthe free base was obtained in the same manner as in Example 57

Sources & evidence

ORD record
ord-052d46481e2d4a2dbdd0785a0a942a9f
Source dataset
uspto-grants-2007_04
Patent number
US07208495B2

Reaction notes

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