Indomethacin → HCID 178487187, compound

HRID 1273114Notes

Reaction equation

HRID 1273114 reaction equation
COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1.N#Cc1ccc(N)cc1C(F)(F)F>CN(C)C=O.Cc1cccc(C)n1.F[P-](F)(F)(F)(F)F.c1ccc2c(c1)nnn2O[P+](N1CCCC1)(N1CCCC1)N1CCCC1>COc1ccc2c(c1)c(CC(=O)Nc1ccc(C#N)c(C(F)(F)F)c1)c(C)n2C(=O)c1ccc(Cl)cc1

Participants

6

Reactant 2

HCID 3715IndomethacinHCID 5221704-Amino-2-(trifluoromethyl)benzonitrile

Product 1

HCID 178487187HCID 178487187, compoundYield 0.21%

Reagents, catalysts & solvents 3

HCID 79372,6-LutidineReagentHCID 2724699PyBOPReagentHCID 6228DimethylformamideSolvent2×

Conditions

Temperature
25 °C

Workup

  1. additiondilution
  2. stirringNo procedure recorded
  3. aliquotNo procedure recorded
  4. additiondilute aliquot with HPLC solvents
  5. filtrationfilter for UPLC-MS · Keep liquid (mobile)

Sources & evidence

ORD record
ord-762f05737bdd4e21b2d7dc3ca54610ec
Source dataset
Aniline amide coupling reaction
Original link
View source

Reaction notes

Loading…