Ethyl Glycolate → HCID 54447241, compound

HRID 1283092Notes

Reaction equation

HRID 1283092 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH2:2][OH:3].[H-].[Na+].Cl[C:11]1[N:16]=[C:15]([Cl:17])[CH:14]=[C:13]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[N:12]=1>O1CCCC1>[CH2:6]([O:5][C:1](=[O:4])[CH2:2][O:3][C:11]1[N:16]=[C:15]([Cl:17])[CH:14]=[C:13]([NH:18][CH2:19][C:20]2[CH:25]=[CH:24][C:23]([Cl:26])=[CH:22][CH:21]=2)[N:12]=1)[CH3:7]

Participants

5

Reactant 3

HCID 12184Ethyl GlycolateHCID 24758Sodium hydrideHCID 21519299HCID 21519299, compound

Product 1

HCID 54447241HCID 54447241, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 4.2 g. of ethyl glycolate in 50 ml. of anhydrous tetrahydrofuran was added 1.7 g. of sodium hydride oil dispersion (57 percent) with stirring. There was added after 20 minutes 11.5 g. of 2,4-dichloro-6-(p-chlorobenzylamino)pyrimidine.

Workup

  1. additionThere was added after 20 minutes 11.5 g

Sources & evidence

ORD record
ord-37d0c351035f462395e7775d0c3e1d96
Source dataset
uspto-grants-1976_08
Patent number
US03974162

Reaction notes

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