Hydrochloric Acid → HCID 68138797, compound

HRID 1283142Notes

Reaction equation

HRID 1283142 reaction equation
[C:1]([Cl:4])(=[O:3])[CH3:2].[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:15]2[CH2:20][CH2:19][CH2:18][CH2:17][C:16]2([CH:22]([CH3:27])[CH2:23][N:24]([CH3:26])[CH3:25])[OH:21])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14].Cl>C(O)(C)C.O1CCCC1.CCOCC>[ClH:4].[C:1]([O:21][C:16]1([CH:22]([CH3:27])[CH2:23][N:24]([CH3:26])[CH3:25])[CH2:17][CH2:18][CH2:19][CH2:20][CH:15]1[C:9]1[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:7]([O:6][CH3:5])[CH:8]=1)(=[O:3])[CH3:2]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 21519224HCID 21519224, compound

Product 1

HCID 68138797HCID 68138797, compound

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

The procedure of Example I(c) is followed using 6.5 ml acetyl chloride and 11.5 g 2-(3,4-Dimethoxyphenyl)-1-(2-dimethylamino-1-methylethyl)cyclohexanol and a reaction time of 6 hours to give 9.5 g. crude HCl salt which is dissolved in 50 ml isopropanol and diluted with 440 ml tetrahydrofuran and 60 ml ether to give 7.1 g product, m. 200°.

Workup

  1. customa reaction time of 6 hours to give 9.5 g

Sources & evidence

ORD record
ord-b607d7fbb3774d238f77f747124b1e98
Source dataset
uspto-grants-1976_08
Patent number
US03974157

Reaction notes

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