Hydrochloric Acid → HCID 21518480, compound

HRID 1283584Notes

Reaction equation

HRID 1283584 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([Cl:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9](Cl)[N:8]=2)[CH2:3][CH2:2]1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.Cl.O>C1(OC2C=CC=CC=2)C=CC=CC=1>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([Cl:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 4837PiperazineHCID 21518492HCID 21518492, compound

Product 1

HCID 21518480HCID 21518480, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

1-Thiomorpholino-3-piperazino-5-chloro-isoquinoline was prepared analogous to Example 3 from 1-thiomorpholino-3,5-dichloro-isoquinoline and piperazine by heating in diphenyl ether at 200°C. M.p. of its hydrochloride: 273°-275°C (from water); yield: 97% of theory.

Sources & evidence

ORD record
ord-324dba09a8c44665ac99663d1f6eda93
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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