Isopropanol → HCID 21518487, compound

HRID 1283586Notes

Reaction equation

HRID 1283586 reaction equation
[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([F:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9](Cl)[N:8]=2)[CH2:3][CH2:2]1.[NH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.C(O)(C)C>C1(OC2C=CC=CC=2)C=CC=CC=1>[S:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:16]3[C:11](=[C:12]([F:17])[CH:13]=[CH:14][CH:15]=3)[CH:10]=[C:9]([N:19]3[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]3)[N:8]=2)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 3776IsopropanolHCID 4837PiperazineHCID 21518469HCID 21518469, compound

Product 1

HCID 21518487HCID 21518487, compoundYield 90%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

1-Thiomorpholino-3-piperazino-5-fluoro-isoquinoline was prepared analogous to Example 3 from 1-thiomorpholino-3-chloro-5-fluoro-isoquinoline by heating for 30 hours with piperazine in diphenyl ether at 200°C. M.p. 213°-215°C (from isopropanol); yield: 90% of theory.

Sources & evidence

ORD record
ord-37fb5301cec14192afced9cc79d80c91
Source dataset
uspto-grants-1976_08
Patent number
US03975524

Reaction notes

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