Sodium Iodide → HCID 885478, compound

HRID 1283894Notes

Reaction equation

HRID 1283894 reaction equation
[Cl:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=[O:8].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].[CH2:21](Cl)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>C(O)C>[CH2:21]([O:12][C:3]1[C:2]([Cl:1])=[CH:9][C:6]([CH:7]=[O:8])=[CH:5][C:4]=1[O:10][CH3:11])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

6

Reactant 4

HCID 5238Sodium IodideHCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 296223-Chloro-4-hydroxy-5-methoxybenzaldehyde

Product 1

HCID 885478HCID 885478, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

5-Chlorovanillin (60 g., 0.32 m.), 46.8 g. of potassium carbonate (0.34 m.), 1.9 g. of sodium iodide in 1.4 l. of ethanol and 46.8 g. (0.37 m.) of benzyl chloride in 200 ml. of ethanol are reacted to give 4-benzyloxy-5-chloro-3-methoxybenzaldehyde as an orange liquid which is employed for conversion of the epoxide without purification.

Sources & evidence

ORD record
ord-0f13a5119de54429be85b946d146f855
Source dataset
uspto-grants-1976_08
Patent number
US03976695

Reaction notes

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