3-Bromopyridine → Biphenyl

HRID 1286710Notes

Reaction equation

HRID 1286710 reaction equation
Brc1cccnc1.c1ccc(Pc2ccccc2)cc1>C1CCC2=NCCCN2CC1.CC(C)(C)[P](C(C)(C)C)(C(C)(C)C)->[Pd]1([Cl])<-[NH2]c2ccccc2-c2cccc[c]21.CS(C)=O>c1ccc(P(c2ccccc2)c2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 70017Diphenylphosphine

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 70017DiphenylphosphineHCID 11334531HCID 11334531, compound

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178454887HCID 178454887, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-c85397177b2b4448855bc25565159c33
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

Loading…