3-Bromopyridine → Biphenyl

HRID 1286764Notes

Reaction equation

HRID 1286764 reaction equation
Brc1cccnc1.c1ccc(Pc2ccccc2)cc1>C1CCC2=NCCCN2CC1.CC(C)c1cc(C(C)C)c(-c2ccccc2[P](C(C)(C)C)(C(C)(C)C)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(C)(=O)=O)c(C(C)C)c1.CS(C)=O>c1ccc(P(c2ccccc2)c2cccnc2)cc1

Participants

9

Reactant 2

HCID 122863-BromopyridineHCID 70017Diphenylphosphine

Product 4

HCID 7095BiphenylHCID 122863-BromopyridineHCID 70017DiphenylphosphineHCID 11334531HCID 11334531, compound

Reagents, catalysts & solvents 3

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneReagentHCID 178439022HCID 178439022, compoundReagentHCID 679Dimethyl SulfoxideSolvent4×

Procedure

The Mosquito was used to combine the source plate solutions by multi-aspiration of 250 nL of each of the four reaction components and then to dose the resulting reaction mixture (1 uL) into a 1536-well plate

Workup

  1. additionNo procedure recorded
  2. aliquotNo procedure recorded
  3. additionNo procedure recorded

Sources & evidence

ORD record
ord-8b70429453df4d96b41f6f1605deb34d
Source dataset
HTE Pd-catalyzed cross-coupling screen
Original link
View source

Reaction notes

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