反应详情

Sodium hydride (4.2 g of 60% dispersion in oil) is added to a solution of 4-hydroxybenzaldehyde (12.2 g) in dimethylformamide. The mixture is stirred for 30 min, and 1-bromooctane (18 ml) is added. The reaction mixture is stirred at 90° for five hours, cooled, and the solvent removed in vacuo. The residue is shaken with water, and extracted with three portions of hexane. The hexane extracts are dried, concentrated, and distilled in vacuo to provide 20.3 g of 4-octyloxybenzaldehyde.

1. stirringThe reaction mixture is stirred at 90° for five hours
2. temperaturecooled
3. customthe solvent removed in vacuo
4. stirringThe residue is shaken with water
5. extractionextracted with three portions of hexane
6. dry with materialThe hexane extracts are dried
7. concentrationconcentrated
8. distillationdistilled in vacuo