Methyl iodide → HCID 53744550, compound

HRID 1288167Notes

Reaction equation

HRID 1288167 reaction equation
[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([OH:22])[CH2:7]1)=[O:5])[CH3:2].[Na].[H-].[Na+].[CH3:26]I>O1CCCC1>[CH2:1]([O:3][C:4]([N:6]1[CH2:20][CH2:19][C:18]2[C:9](=[N:10][C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][C:16]=3[C:17]=2[CH3:21])[CH:8]([O:22][CH3:26])[CH2:7]1)=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 5360545SodiumHCID 53875304HCID 53875304, compound

Product 1

HCID 53744550HCID 53744550, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

2 gm (6.65 millimols) of 5-hydroxy-1,2,4,5-tetrahydro-11-methyl-3-azepino[4,5-b]quinoline-carboxylic acid ethyl ester were converted into the sodium salt in 50 ml of absolute tetrahydrofuran with 0.32 gm (7 millimols) of 50% sodium hydride, and the salt was methylated with 0.43 ml (7 millimols) of methyl iodide.

Sources & evidence

ORD record
ord-dcf75a0daf3e4a969ea902ba14092028
Source dataset
uspto-grants-1976_10
Patent number
US03987047

Reaction notes

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