Water → HCID 15343903, compound

HRID 1291695Notes

Reaction equation

HRID 1291695 reaction equation
F[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=1[C:12]([F:15])([F:14])[F:13].[OH:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1.C([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[N:19]1[CH:20]=[CH:21][CH:22]=[C:17]([O:16][C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][C:3]=2[C:12]([F:15])([F:14])[F:13])[CH:18]=1

Participants

6

Reactant 4

HCID 962WaterHCID 79713-HydroxypyridineHCID 11430Potassium CarbonateHCID 15285559Methyl 4-fluoro-3-(trifluoromethyl)benzoate

Product 1

HCID 15343903HCID 15343903, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2 mmol of methyl 4-fluoro-3-trifluoromethylbenzoate, 2 mmol of 3-hydroxypyridine and 4 mmol of K2CO3 were stirred at 110° C. for 1.5 h in 15 ml of DMF (anhydrous). The mixture was then poured onto 100 ml of water and extracted 3 times using 50 ml of EA each time. It was dried over Na2SO4, the solvent was removed in vacuo and the product was reacted further without further purification.

Workup

  1. extractionextracted 3 times
  2. dry with materialIt was dried over Na2SO4
  3. customthe solvent was removed in vacuo
  4. customthe product was reacted further without further purification

Sources & evidence

ORD record
ord-9405b021da3540098ab3ccb14363cd11
Source dataset
uspto-grants-1998_05
Patent number
US05753710

Reaction notes

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