反应详情

温度

140 °C

A mixture of 2-fluoro-4-trifluoromethylbenzamide (5.60 g, 27.05 mmol.), K2CO3 (11.2 g, 81.16 mmol), allylamine (7.71 g, 135.26 mmol) and dimethylacetamide (50 mL) was heated at 140° C. for 18 hours. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (100 mL) and washed with a solution of aqueous saturated sodium bicarbonate (3×100 mL). The ethyl acetate layer was dried over sodium sulfate and concentrated to give the title compound (6.5 g, 98% yield) as a brown solid.

1. temperatureThe reaction mixture was cooled to room temperature
2. washwashed with a solution of aqueous saturated sodium bicarbonate (3×100 mL)
3. dry with materialThe ethyl acetate layer was dried over sodium sulfate
4. concentrationconcentrated