反应详情

温度

100 °C

A mixture of 4-chloro-2-fluoro-nitrobenzene (28.5 mmol), 1-methylpiperazine (28.5 mmol) and K2CO3 (37.0 mmol) in DMF is stirred at 100° C. for 16 h and diluted with water and EtOAc. The phases are separated and the aqueous phase is extracted with EtOAc. The organic phase and the extracts are combined, washed sequentially with water and brine, dried over Na2SO4 and dried in vacuo. The resultant residue is chromatographed (silica gel, 10% methanol in EtOAc as eluent) to afford the title product.

1. customThe phases are separated
2. extractionthe aqueous phase is extracted with EtOAc
3. washwashed sequentially with water and brine
4. dry with materialdried over Na2SO4
5. customdried in vacuo
6. customThe resultant residue is chromatographed (silica gel, 10% methanol in EtOAc as eluent)