反应详情

After dissolving the 4-(azidomethyl)-5-bromo-2-ethoxybenzoic acid (7.67 g) in tetrahydrofuran (100 ml), triethylamine (3.2 ml) and ethyl chloroformate (2.11 ml) were added in that order and the mixture was stirred at room temperature for 30 minutes. Aqueous methylamine (3.2 ml) was added and the mixture was stirred at room temperature for 30 minutes. The mixture was diluted with ethyl acetate and washed with water and 1 N hydrochloric acid, and then the organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated to yield the title compound (5.328 g) as a white solid.

1. additionwere added in that order
2. stirringthe mixture was stirred at room temperature for 30 minutes
3. washwashed with water and 1 N hydrochloric acid
4. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. concentrationconcentrated