Piperazine → HCID 18186864, compound

HRID 1296677Notes

Reaction equation

HRID 1296677 reaction equation
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[N:3]=1.C(O)CCCCC.[NH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.C([O-])([O-])=O.[K+].[K+]>>[CH2:9]([O:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[N:3]=1)[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14]

Participants

5

Reactant 4

HCID 4837PiperazineHCID 81031-HexanolHCID 11430Potassium CarbonateHCID 18186938HCID 18186938, compound

Product 1

HCID 18186864HCID 18186864, compound

Procedure

The title compound was prepared according to the procedure of example 50, step 2, starting from 2-chloro-6-(n-hexyloxy)pyrazine (1.54 g, 7.17 mmol; obtained according to the procedure of example 50, step 1, starting from n-hexanol), piperazine (1.90 g, 22.1 mmol) and K2CO3 (0.99 g, 7.16 mmol). The yield of the title compound was 1.21 g (64%) which was obtained as a colorless oil. HRMS m/z calcd for C14H24N4O (M)+ 264.1950, found 264.1953. Anal. (C14H24N4O) C, H, N.

Workup

  1. customThe title compound was prepared
  2. customobtained
  3. customwas obtained as a colorless oil

Sources & evidence

ORD record
ord-a07b58d8830747e3930e97bad0095e51
Source dataset
uspto-grants-2007_07
Patent number
US07247633B2

Reaction notes

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