Neopentyl alcohol → HCID 58585841, compound

HRID 1297722Notes

Reaction equation

HRID 1297722 reaction equation
[CH3:1][C:2]([CH3:6])([CH3:5])[CH2:3][OH:4].Cl[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([I:18])[CH:16]=2)[N:11]=[CH:10][C:9]=1[C:19]#[N:20].[H-].[K+]>C1COCC1>[CH3:1][C:2]([CH3:6])([CH3:5])[CH2:3][O:4][C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([I:18])[CH:16]=2)[N:11]=[CH:10][C:9]=1[C:19]#[N:20]

Participants

5

Reactant 3

HCID 6404Neopentyl alcoholHCID 82127Potassium hydrideHCID 224667694-Chloro-6-iodoquinoline-3-carbonitrile

Product 1

HCID 58585841HCID 58585841, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Similar procedure as described in example 28a was used, starting from 2,2-dimethyl-1-propanol, 4-chloro-6-iodo-quinoline-3-carbonitrile (example 14c) and potassium hydride in a solvent system of THF to give 4-(2,2-dimethyl-propoxy)-6-iodo-quinoline-3-carbonitrile. LC-MS m/e 367 (MH+).

Sources & evidence

ORD record
ord-a7db65f984ee4eae8de66e0df733369a
Source dataset
uspto-grants-2007_07
Patent number
US07250515B2

Reaction notes

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