Acetate → Ethyl 3-(6-aminopyridine-3-yl)acrylate

HRID 134982Notes

Reaction equation

HRID 134982 reaction equation
[C:18]([CH:19]=[CH2:20])(=[O:21])[O:22][CH2:23][CH3:24].[C:52]([O-:53])(=[O:54])[CH3:55].[C:57]([O-:58])(=[O:59])[CH3:60].[CH3:25][c:26]1[cH:27][cH:28][cH:29][cH:30][c:31]1[P:32]([c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[CH3:39])[c:40]1[cH:41][cH:42][cH:43][cH:44][c:45]1[CH3:46].[CH3:47][N:48]([CH3:49])[CH:50]=[O:51].[CH:9]([N:10]([CH2:11][CH3:12])[CH:13]([CH3:14])[CH3:15])([CH3:16])[CH3:17].[NH2:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][cH:7]1.[Pd+2:56]>>[NH2:1][c:2]1[n:3][cH:4][c:5]([CH:20]=[CH:19][C:18](=[O:21])[O:22][CH2:23][CH3:24])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6228DimethylformamideHCID 8821Ethyl AcrylateHCID 706222-Amino-5-bromopyridineHCID 80271Tri-o-tolylphosphineHCID 81531DiisopropylethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

Product 1

HCID 53409341Ethyl 3-(6-aminopyridine-3-yl)acrylate

Sources & evidence

ORD record
ord-3768270bc39a4ae59c40f858ec0a3627
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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