Dimethyl Sulfoxide → HCID 18507647, compound

HRID 1355691Notes

Reaction equation

HRID 1355691 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:10]=[CH:11][CH:12]=1)[C:5]([CH2:7][C:8]#[N:9])=O.[H-].[Na+].CI.[N+]([O-])(O)=O.[NH2:21][C:22]([NH2:24])=[NH:23].[CH3:25][S:26]([CH3:28])=O>CN(C=O)C.C(N(CC)CC)C.C(=S)=S>[NH2:23][C:22]1[N:24]=[C:25]([S:26][CH3:28])[C:7]([C:8]#[N:9])=[C:5]([C:4]2[CH:3]=[C:2]([CH3:1])[CH:12]=[CH:11][CH:10]=2)[N:21]=1

Participants

9

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodideHCID 10481Guanidine NitrateHCID 24758Sodium hydrideHCID 1431053-Toluoylacetonitrile

Product 1

HCID 18507647HCID 18507647, compound

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideSolventHCID 6348Carbon DisulfideSolventHCID 8471TriethylamineSolvent

Procedure

From 3-methylbenzoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 256 (M+, 74), 255 ([M—H]+, 100), 241 ([M—CH3]+, 98).

Sources & evidence

ORD record
ord-fa8d689c2d464c6687eb6c91befe7485
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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