Dimethyl Sulfoxide → HCID 2819127, compound

HRID 1355694Notes

Reaction equation

HRID 1355694 reaction equation
[C:1]1([C:6]([CH2:8][C:9]#[N:10])=O)[S:5][CH:4]=[CH:3][CH:2]=1.[H-].[Na+].CI.[N+]([O-])(O)=O.[NH2:19][C:20]([NH2:22])=[NH:21].[CH3:23][S:24]([CH3:26])=O>CN(C=O)C.C(N(CC)CC)C.C(=S)=S>[NH2:21][C:20]1[N:22]=[C:23]([S:24][CH3:26])[C:8]([C:9]#[N:10])=[C:6]([C:1]2[S:5][CH:4]=[CH:3][CH:2]=2)[N:19]=1

Participants

9

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodideHCID 10481Guanidine NitrateHCID 24758Sodium hydrideHCID 1418532-Thenoylacetonitrile

Product 1

HCID 2819127HCID 2819127, compound

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideSolventHCID 6348Carbon DisulfideSolventHCID 8471TriethylamineSolvent

Procedure

From 2-thenoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%): 248 (M+, 42), 247 ([M—H]+, 100).

Sources & evidence

ORD record
ord-1dce7ac0de0c4de9bda205b729cc85a1
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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