Dimethyl Sulfoxide → HCID 12451273, compound

HRID 1355695Notes

Reaction equation

HRID 1355695 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([CH2:8][C:9]#[N:10])=O.[H-].[Na+].CI.[N+]([O-])(O)=O.[NH2:19][C:20]([NH2:22])=[NH:21].[CH3:23][S:24]([CH3:26])=O>CN(C=O)C.C(N(CC)CC)C.C(=S)=S>[NH2:21][C:20]1[N:22]=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[C:8]([C:9]#[N:10])=[C:23]([S:24][CH3:26])[N:19]=1

Participants

9

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6328Methyl iodideHCID 10481Guanidine NitrateHCID 24758Sodium hydrideHCID 1416712-Furoylacetonitrile

Product 1

HCID 12451273HCID 12451273, compound

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideSolventHCID 6348Carbon DisulfideSolventHCID 8471TriethylamineSolvent

Procedure

From 2-furoylacetonitrile with sodium hydride, carbon disulphide and methyl iodide in DMSO. Then treatment with guanidine nitrate and triethylamine in DMF. EI-MS m/e (%):232 (M+, 40), 231 ([M—H]+, 100).

Sources & evidence

ORD record
ord-6a78ac6277dd4855b49949037a8f46c9
Source dataset
uspto-grants-2003_07
Patent number
US06586441B2

Reaction notes

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