Hydrochloric Acid → HCID 88064075, compound

HRID 1358205Notes

Reaction equation

HRID 1358205 reaction equation
[CH2:1]([O:3][P:4]([C:9]1[C:10](=[O:24])[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([S:19](Cl)(=[O:21])=[O:20])=[C:14]([Cl:23])[CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2].Cl.C(OCC)(=O)C.[OH-].[NH4+:33]>>[CH2:1]([O:3][P:4]([C:9]1[C:10](=[O:24])[NH:11][C:12]2[C:17]([CH:18]=1)=[CH:16][C:15]([S:19](=[O:21])(=[O:20])[NH2:33])=[C:14]([Cl:23])[CH:13]=2)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 14923Ammonium HydroxideHCID 88063986HCID 88063986, compound

Product 1

HCID 88064075HCID 88064075, compound

Procedure

A suspension of the compound obtained in Step E (1.26 g, 3.0 mmol) in 18 ml of 28 % ammonium hydroxide is stirred. After a few minutes, dissolution is observed. Stirring is continued for 30 minutes and the reaction mixture is acidified with 4N HCl. A few ml of ethyl acetate are added, with stirring, and precipitation is produced. The precipitate is filtered off and dried in vacuo to yield the title product in the form of cream-coloured powder.

Workup

  1. waitAfter a few minutes
  2. dissolutiondissolution
  3. stirringStirring
  4. stirringwith stirring
  5. customprecipitation
  6. customis produced
  7. filtrationThe precipitate is filtered off
  8. customdried in vacuo

Sources & evidence

ORD record
ord-63a37cb39a7d42b68be35195f31c8f47
Source dataset
uspto-grants-2003_07
Patent number
US06596709B1

Reaction notes

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