Dimethylformamide → 4-chloro-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

HRID 135921Notes

Reaction equation

HRID 135921 reaction equation
[CH3:65][N:66]([CH3:67])[CH:68]=[O:69].[CH3:70][CH2:71][O:72][C:73](=[O:74])[CH3:75].[CH:56]([N:57]([CH:58]([CH3:59])[CH3:60])[CH2:61][CH3:62])([CH3:63])[CH3:64].[NH2:1][C:2]1([C:5](=[O:6])[NH:7][CH:8]2[c:9]3[n:10]([cH:19][cH:20][n:21]3)-[c:11]3[c:12]([cH:15][cH:16][cH:17][cH:18]3)[CH2:13][CH2:14]2)[CH2:3][CH2:4]1.[OH:22][C:23](=[O:24])[c:25]1[cH:26][cH:27][c:28]([Cl:29])[cH:30][cH:31]1.[P-:32]([F:33])([F:34])([F:35])([F:36])([F:37])[F:38].[n:39]1([O:40][C:41]([N:42]([CH3:43])[CH3:44])=[N+:45]([CH3:46])[CH3:47])[c:48]2[n:49][cH:50][cH:51][cH:52][c:53]2[n:54][n:55]1>>[NH:1]([C:2]1([C:5](=[O:6])[NH:7][CH:8]2[c:9]3[n:10]([cH:19][cH:20][n:21]3)-[c:11]3[c:12]([cH:15][cH:16][cH:17][cH:18]3)[CH2:13][CH2:14]2)[CH2:3][CH2:4]1)[C:23](=[O:22])[c:25]1[cH:26][cH:27][c:28]([Cl:29])[cH:30][cH:31]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 63184-Chlorobenzoic AcidHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 672342911-amino-N-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-yl)cyclopropane-1-carboxamide

Product 1

HCID 672345324-chloro-N-[1-(5,6-dihydro-4H-imidazo[1,2-a][1]benzazepin-4-ylcarbamoyl)cyclopropyl]benzamide

Sources & evidence

ORD record
ord-043b5dfe80b3418285fa787e06e2f653
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

Loading…