Acetic Acid → N-(1-ethylpropyl)-3,4,5-trifluoroaniline

HRID 1360656Notes

Reaction equation

HRID 1360656 reaction equation
[CH3:1][CH2:2][C:3](=O)[CH2:4][CH3:5].C(O)(=O)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].[F:25][C:26]1[CH:27]=[C:28]([CH:30]=[C:31]([F:34])[C:32]=1[F:33])[NH2:29]>ClCCCl>[CH2:2]([CH:3]([NH:29][C:28]1[CH:27]=[C:26]([F:25])[C:32]([F:33])=[C:31]([F:34])[CH:30]=1)[CH2:4][CH3:5])[CH3:1]

Participants

6

Reactant 4

HCID 176Acetic AcidHCID 7288Ethyl ketoneHCID 27249913,4,5-TrifluoroanilineHCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 23117858N-(1-ethylpropyl)-3,4,5-trifluoroaniline

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

3-Pentanone, acetic acid and sodium triacetoxyborohydride were added to a 1,2-dichloroethane solution of 3,4,5-trifluoroaniline, for stirring at ambient temperature for 14 hours, to obtain N-(1-ethylpropyl)-3,4,5-trifluoroaniline.

Sources & evidence

ORD record
ord-c2508dfe0bc74d39a0ce7973d1a6a43f
Source dataset
uspto-grants-2011_02
Patent number
US07879878B2

Reaction notes

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