Ammonia → HCID 131728667, compound

HRID 1363374Notes

Reaction equation

HRID 1363374 reaction equation
[N:1]([CH2:4][C@H:5]1[C@H:9]([C:10]2[C:11]([O:30][CH3:31])=[CH:12][C:13]([O:28][CH3:29])=[C:14]3[C:19]=2[O:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])=[CH:16][C:15]3=[O:27])[CH2:8][CH2:7][N:6]1[CH3:32])=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O.N>C1COCC1.C(Cl)(Cl)Cl.CC(O)C>[NH2:1][CH2:4][C@H:5]1[C@H:9]([C:10]2[C:11]([O:30][CH3:31])=[CH:12][C:13]([O:28][CH3:29])=[C:14]3[C:19]=2[O:18][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[Cl:26])=[CH:16][C:15]3=[O:27])[CH2:8][CH2:7][N:6]1[CH3:32]

Participants

8

Reactant 4

HCID 222AmmoniaHCID 962WaterHCID 11776TriphenylphosphineHCID 131728668HCID 131728668, compound

Product 1

HCID 131728667HCID 131728667, compound

Reagents, catalysts & solvents 3

HCID 3776IsopropanolSolventHCID 6212ChloroformSolventHCID 8028TetrahydrofuranSolvent

Procedure

Compound of example 107 (0.6 g, 1.32 mmol) and triphenylphosphine (0.414 g, 1.58 mmol) were dissolved in THF (10 mL) containing water (0.1 mL). The resultant solution was stirred for 12 h. It was concentrated and the residue obtained was subjected to flash column chromatography using 5% IPA+1% liquor NH3 in CHCl3 as eluant to obtain the title compound.

Workup

  1. concentrationIt was concentrated
  2. customthe residue obtained

Sources & evidence

ORD record
ord-a4db8d55dabe449ea8d79c181fd7a36e
Source dataset
uspto-grants-2011_02
Patent number
US07884127B2

Reaction notes

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